Laboratory of Bioregulation Chemistry

2024

• Aoki, J.; Yarita, T.; Hasegawa, M.; Asayama, M. Development of a new extraction method and functional analysis of phycocyanobilin from unique filamentous cyanobacteria. J. Biotechnol. in press..
• 鳥居塚南; 上原由理香; 長谷川守文; 渡辺卓穂; 鎗田孝. 親水性-疎水性バランス型充填剤を用いる簡便な固相抽出精製による二枚貝中オカダ酸群の精密定量. 分析化学 2024, 73, 185–191.

2021

• 関浩一; 長谷川守文; 小松﨑将一. 薬用シャクヤク栽培での中耕と草生管理の差異がペオニフロリン含有率と収量に及ぼす影響. 農作業研究 2021, 56, 189–196.
• Miyata, U.; Arakawa, K.; Takei, M.; Asami, T.; Asanbou, K.; Toshima, H.; Suzuki, Y. Identification of an aromatic aldehyde synthase involved in indole-3-acetic acid biosynthesis in the galling sawfly (Pontania sp.) and screening of an inhibitor. Insect Biochem. Mol. Biol. 2021, 137, 103639.

2020

• Zhan, C.; Lei, L.; Liu, Z.; Zhou, S.; Yang, C.; Zhu, X.; Guo, H.; Zhang, F.; Peng, M.; Zhang, M.; Li, Y.; Yang, Z.; Sun, Y.; Shi, Y.; Li, K.; Liu, L.; Shen, S.; Wang, X.; Shao, J.; Jing, X.; Wang, Z.; Li, Y.; Czechowski, T.; Hasegawa, M.; Graham, I.; Tohge, T.; Qu, L.; Liu, X.; Fernie, A.R.; Chen, L.-L.; Yuan, M.; Luo, J. Selection of a subspecies-specific diterpene gene cluster implicated in rice disease resistance. Nat. Plants 2020, 6, 1447–1454.

2019

• Arofatullah, N.A.; Hasegawa, M.; Tanabata, S.; Ogiwara, I.; Sato, T. Heat shock-induced resistance against Pseudomonas syringae pv. tomato (Okabe) Young et al. via heat shock transcription factors in tomato. Agronomy 2019, 9, 2.

2018

• Kudo, K.; Liu, C.; Matsumoto, T.; Minami, A.; Ozaki, T.; Toshima, H.; Gomi, K.; Oikawa, H. Heterologous biosynthesis of fungal indole sesquiterpene sespendole. ChemBioChem 2018, 19, 1492–1497.
• 浅木直美; 窪田俊仁; 坂上伸生; 岡田拓也; 長谷川守文; 磯野健雄; 新田洋司. スィートソルガム栽培の有無と残渣の施用方法がウコン根茎の収量とクルクミン濃度におよぼす影響. 農作業研究 2018, 53, 149–157
• Katsumata, S.; Toshima, H.; Hasegawa, M. Xylosylated detoxification of the rice flavonoid phytoalexin sakuranetin by the rice sheath blight fungus Rhizoctonia solani. Molecules 2018, 23, 276.
• Ootsuka, M.; Nishizawa, T.; Hasegawa, M.; Kurusu, Y.; Ohta, H. Comparative analysis of the genetic basis of branched nonylphenol degradation by Sphingobium amiense DSM 16289T and Sphingobium cloacae JCM 10874T. Microbes Environ. 2018, 33, 450–454.

2017

• Katsumata, S.; Hamana, K.; Horie, K.; Toshima, H.; Hasegawa, M. Identification of sternbin and naringenin as detoxified metabolites from the rice flavanone phytoalexin sakuranetin by Pyricularia oryzae. Chem. Biodiversity 2017, 14, e1600240.
• Buwat, N.; Hasegawa, M.; Umponstira, C. Combining effects of ozone and Xanthomonas oryzae pv. oryzae on antioxidants and phytoalexins in rice (Oryza sativa L.). Aust. J. Crop Sci. 2017, 11, 1626–1634.

2016

• Horie, K.; Sakai, K.; Okugi, M.; Toshima, H.; Hasegawa, M. Ultraviolet-induced amides and casbene diterpenoids from rice leaves. Phytochem. Lett. 2016, 15, 57–62.
• Eguchi, Y.; Widiastuti, A.; Odani, H.; Chinta, Y.D.; Shinohara, M.; Misu, H.; Kamoda, H.; Watanabe, T.; Hasegawa, M.; Sato, T. Identification of terpenoids volatilized from Thymus vulgaris L. by heat treatment and their in vitro antimicrobial activity. Physiol. Mol. Plant Pathol. 2016, 94, 83–89.
• Miyamoto, K.; Fujita, M.; Shenton, M.R.; Akashi, S.; Sugawara, C.; Sakai, A.; Horie, K.; Hasegawa, M.; Kawaide, H.; Mitsuhashi, W.; Nojiri, H.; Yamane, H.; Kurata, N.; Okada, K.; Toyomasu, T. Evolutionary trajectory of phytoalexin biosynthetic gene clusters in rice. Plant J. 2016, 87, 293–304.
• Fujiwara, A.; Nishi, M.; Yoshida, S.; Hasegawa, M.; Yasuma, C.; Ryo, A.; Suzuki, Y. Eucommicin A, a β-truxinate lignan from Eucommia ulmoides, is a selective inhibitor of cancer stem cells. Phytochemistry 2016, 122, 139–145.
• Toyomasu, T.; Miyamoto, K.; Shenton, M.R.; Sakai, A.; Sugawara, C.; Horie, K.; Kawaide, H.; Hasegawa, M.; Chuba, M.; Mitsuhashi, W.; Yamane, H.; Kurata, N.; Okada, K. Characterization and evolutionary analysis of ent-kaurene synthase like genes from the wild rice species Oryza rufipogon. Biochem. Biophys. Res. Commun. 2016, 480, 402–408.

2015

• Horie, K.; Inoue, Y.; Sakai, M.; Yao, Q.; Tanimoto, Y.; Koga, J.; Toshima, H.; Hasegawa, M. Identification of UV-induced diterpenes including a new diterpene phytoalexin, phytocassane F, from rice leaves by complementary GC/MS and LC/MS approaches. J. Agric. Food Chem. 2015, 63, 4050–4059.
• Hondo, S.; Takahashi, M.; Osanai, T.; Matsuda, M.; Hasunuma, T.; Tazuke, A.; Nakahira, Y.; Chohnan, S.; Hasegawa, M.; Asayama, M. Genetic engineering and metabolite profiling for overproduction of polyhydroxybutyrate in cyanobacteria. _ J. Biosci. Bioeng._ 2015, 120, 510–517.
• Takei, M.; Yoshida, S.; Kawai, T.; Hasegawa, M.; Suzuki, Y. Adaptive significance of gall formation for a gall-inducing aphids on Japanese elm trees. _ J. Insect Physiol._ 2015, 72, 43–51.

2014

• Toyomasu, T.; Usui, M.; Sugawara, C.; Otomo, K.; Hirose, Y.; Miyao, A.; Hirochika, H.; Okada, K.; Shimizu, T.; Koga, J.; Hasegawa, M.; Chuba, M.; Kawana, Y.; Kuroda, M.; Minami, E.; Mitsuhashi, W.; Yamane, H. Reverse genetic approach to verify physiological roles of rice phytoalexins: characterization of a knockdown mutant of OsCPS4 phytoalexin biosynthetic gene in rice. Physiol. Plant. 2014, 150, 55–62.
• Hasegawa, M.; Mitsuhara, I.; Seo, S.; Okada, K.; Yamane, H.; Iwai, T.; Ohashi, Y. Analysis on blast fungus-responsive characters of a flavonoid phytoalexin sakuranetin; accumulation in infected rice leaves, antifungal activity and detoxification by fungus. Molecules 2014, 19, 11404–11418.

2013

• Liu, C.; Minami, A.; Noike, M.; Toshima, H.; Oikawa, H.; Dairi, T. Regiospecificities and prenylation mode specificities of the fungal indole diterpene prenyltransferases AtmD and PaxD. Appl. Environ. Microbiol. 2013, 79, 7298–7304.
• Shimomura, S.; Oyama, S.; Nakano, K.; Hasegawa, M.; Toshima, H. Stereoselective synthesis of a promising flower-inducing KODA analog, (9R,12S,13R,15Z)-9-hydroxy-12,13-methylene-10-oxooctadec-15-enoic acid. Biosci. Biotechnol. Biochem. 2013, 77, 1354–1357.
• Inoue, Y.; Sakai, M.; Yao, Q.; Tanimoto, Y.; Toshima, H.; Hasegawa, M. Identification of a novel casbane-type diterpene phytoalexin, ent-10-oxodepressin, from rice leaves. Biosci. Biotechnol. Biochem. 2013, 77, 760–765.
• Tagami, K.; Liu, C.; Minami, A.; Noike, M.; Isaka, T.; Fueki, S.; Shichijo, Y.; Toshima, H.; Gomi, K.; Dairi, T.; Oikawa, H. Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae. J. Am. Chem. Soc. 2013, 135, 1260–1263.
• Widiastuti, A.; Yoshino, M.; Hasegawa, M.; Nitta, Y.; Sato, T. Heat shock-induced resistance increases chitinase-1 gene expression and stimulates salicylic acid production in melon (Cucumis melo L.). Physiol. Mol. Plant Pathol. 2013, 82, 51–55.
• Widiastuti, A.; Yoshino, M.; Saito, H.; Maejima, K.; Zhou, S.; Odani, H.; Narisawa, K.; Hasegawa, M.; Nitta, Y.; Sato, T. Heat shock-induced resistance in strawberry against crown rot fungus Colletotrichum gloeosporioides. _ Physiol. Mol. Plant Pathol._ 2013, 84, 86–91.

2012

• 芳野未央子; アニ・ウィディアストゥティ; 周松嬰; 小谷博光; 長谷川守文; 佐藤達雄. キュウリに病害抵抗性を誘導する熱ショック処理方法の改良と処理装置の試作. 園芸学研究 2012, 11, 121–126.
• Shimizu, T.; Lin, F.; Hasegawa, M.; Okada, K.; Nojiri, H.; Yamane, H. Purification and identification of naringenin 7-O-methyltransferase, a key enzyme in the biosynthesis of the flavonoid phytoalexin sakuranetin in rice. J. Biol. Chem. 2012, 287, 19315–19325.
• Yamaguchi, H.; Tanaka, H.; Hasegawa, M.; Tokuda, M.; Asami, T.; Suzuki, Y. Phytohormones and willow gall induction by a gall-inducing sawfly. New Phytol. 2012, 196, 586–595.
• Imai, T.; Ohashi, Y.; Mitsuhara, I.; Seo, S.; Toshima, H.; Hasegawa, M. Identification of a degradation intermediate of the momilactone A rice phytoalexin by the rice blast fungus. Biosci. Biotechnol. Biochem. 2012, 76, 414–416.
• Kanno, H.; Hasegawa, M.; Kodama, O. Accumulation of salicylic acid, jasmonic acid and phytoalexins in rice, Oryza sativa, infested by the white-backed planthopper, Sogatella furcifera (Hemiptera: Delphacidae). Appl. Entomol. Zool. 2012, 47, 27–34.

2011

• 芳野未央子; アニ・ウィディアストゥティ; 長谷川守文; 佐藤達雄. 温湯浸漬を用いた熱ショックにより誘導されるキュウリの灰色かび病抵抗性とその機作. 園芸学研究 2011, 10, 429–433.
• Yajima, A.; Toda, K.; Okada, K.; Yamane, H.; Yamamoto, M.; Hasegawa, M.; Katsuta, R.; Nukada, T. Stereocontrolled total synthesis of (±)-3β-hydroxy-9β-pimara-7,15-diene, a putative biosynthetic intermediate of momilactones. Tetrahedron Lett. 2011, 52, 3212–3215.
• Ikunaga, Y.; Sato, I.; Grond, S.; Numaziri, N.; Yoshida, S.; Yamaya, H.; Hiradate, S.; Hasegawa, M.; Toshima, H.; Koitabashi, M.; Ito, M.; Karlovsky, P.; Tsushima, S. Nocardioides sp. strain WSN05-2, isolated from a wheat field, degrades deoxynivalenol, producing the novel intermediate 3-_epi-deoxynivalenol. Appl. Microbiol. Biotechnol._ 2011, 89, 419–427.
• Widiastuti, A.; Yoshino, M.; Saito, H.; Maejima, K.; Zhou, S.; Odani, H.; Hasegawa, M.; Nitta, Y.; Sato, T. Induction of disease resistance against Botrytis cinerea by heat shock treatment in melon (Cucumis melo L). Physiol. Mol. Plant Pathol. 2011, 75, 157–162.
• Seo, S.; Mitsuhara, I.; Feng, J.; Iwai, T.; Hasegawa, M.; Ohashi, Y. Cyanide, a co-product of plant hormone ethylene biosynthesis, contributes to the resistance of rice to blast fungus. Plant Physiol. 2011, 155, 502–514.
• Isaka, T.; Hasegawa, M.; Toshima, H. Biomimetic cyclization of epoxide precursors of indole mono-, sesqui- and diterpene alkaloids by Lewis acids. Biosci. Biotechnol. Biochem. 2011, 75, 2213–2222.

2010

• Yumoto, K.; Hasegawa, M.; Toshima, H. Synthesis of optically active γ-valerolactone and γ-nonanolactone via optical resolution using chiral amine derived from amino acid. Heterocycles 2010, 81, 421–431.
• Hasegawa, M.; Mitsuhara, I.; Seo, S.; Imai, T.; Koga, J.; Okada, K.; Yamane, H.; Ohashi, Y. Phytoalexin accumulation in the interaction between rice and the blast fungus. Mol. Plant-Microbe Interact. 2010, 23, 1000–1011.
• Kato-Noguchi, H.; Hasegawa, M.; Ino, T.; Ota, K.; Kujime, H. Contribution of momilactone A and B to rice allelopathy. J. Plant Physiol. 2010, 167, 787–791.

2009

• Jiang, C.-J.; Shimono, M.; Maeda, S.; Inoue, H.; Mori, M.; Hasegawa, M.; Sugano, S.; Takatsuji, H. Suppression of the rice fatty-acid desaturase gene OsSSI2 enhances resistance to blast and leaf blight diseases in rice. Mol. Plant-Microbe Interact. 2009, 22, 820–829.

2008

• Yara, A.; Yaeno, T.; Hasegawa, M.; Seto, H.; Seo, S.; Kusumi, K.; Iba, K. Resistance to Magnaporthe grisea in transgenic rice with suppressed expression of genes encoding allene oxide cyclase and phytodienoic acid reductase. Biochem. Biophys. Res. Commun. 2008, 376, 460–465.
• Yara, A.; Yaeno, T.; Montillet, J.-L.; Hasegawa, M.; Seo, S.; Kusumi, K.; Iba, K. Enhancement of disease resistance to Magnaporthe grisea in rice by accumulation of hydroxy linoleic acid. Biochem. Biophys. Res. Commun. 2008, 370, 344–347.
• Shimizu, T.; Jikumaru, Y.; Okada, A.; Okada, K.; Koga, J.; Umemura, K.; Minami, E.; Shibuya, N.; Hasegawa, M.; Kodama, O.; Nojiri, H.; Yamane, H. Effects of a bile acid elicitor, cholic acid, on the biosynthesis of diterpenoid phytoalexins in suspension-cultured rice cells. Phytochemistry 2008, 69, 973–981.
• Toyomasu, T.; Kagahara, T.; Okada, K.; Koga, J.; Hasegawa, M.; Mitsuhashi, W.; Sassa, T.; Yamane, H. Diterpene phytoalexins are biosynthesized in and exuded from the roots of rice seedlings. Biosci. Biotechnol. Biochem. 2008, 72, 562–567.
• Hayashi, Y.; Matsuura, N.; Toshima, H.; Itoh, N.; Ishikawa, J.; Mikami, Y.; Dairi, T. Cloning of the gene cluster responsible for the biosynthesis of brasilicardin A, a unique diterpenoid. J. Antibiot. 2008, 61, 164–174.
• Mashiguchi, K.; Urakami, E.; Hasegawa, M.; Sanmiya, K.; Matsumoto, I.; Yamaguchi, I.; Asami, T.; Suzuki, Y. Defense-related signaling by interaction of arabinogalactan proteins and β-glucosyl Yariv reagent inhibits gibberellin signaling in barley aleurone cells. Plant Cell Physiol. 2008, 49, 178–190.

2007

• 小原直美; 光原一朗; 瀬尾茂美; 大橋祐子; 長谷川守文; 松浦雄介. 酵母抽出液（アグリボEX）処理によるPR遺伝子群発現誘導機構の解析. 日本植物病理学会報 2007, 73, 94–101.
• Rulianti, A.D.; Hasegawa, M.; Ikunaga, Y.; Sato, Y.; Ohta, H. Isolation of octylphenol polyethoxylate-degrading soil bacteria: a long-term soil column study. Microbes Environ. 2007, 22, 391–398.
• Mori, M.; Tomita, C.; Sugimoto, K.; Hasegawa, M.; Hayashi, N.; Dubouzet, J.G.; Ochiai, H.; Sekimoto, H.; Hirochika, H.; Kikuchi, S. Isolation and molecular characterization of a Spotted leaf 18 mutant by modified activation-tagging in rice. Plant Mol. Biol. 2007, 63, 847–860.
• Shimura, K.; Okada, A.; Okada, K.; Jikumaru, Y.; Ko, K.-W.; Toyomasu, T.; Sassa, T.; Hasegawa, M.; Kodama, O.; Shibuya, N.; Koga, J.; Nojiri, H.; Yamane, H. Identification of a biosynthetic gene cluster in rice for momilactones. J. Biol. Chem. 2007, 282, 34013–34018.
• Yara, A.; Yaeno, T.; Hasegawa, M.; Seto, H.; Montillet, J.-L.; Kusumi, K.; Seo, S.; Iba, K. Disease resistance against Magnaporthe grisea is enhanced in transgenic rice with suppression of ω-3 fatty acid desaturases. Plant Cell Physiol. 2007, 48, 1263–1274.

2006

• Kitanaga, Y.; Jian, C.; Hasegawa, M.; Yazaki, J.; Kishimoto, N.; Kikuchi, S.; Nakamura, H.; Ichikawa, H.; Asami, T.; Yoshida, S.; Yamaguchi, I.; Suzuki, Y. Sequential regulation of gibberellin, brassinosteroid, and jasmonic acid biosynthesis occurs in rice coleoptiles to control the transcript levels of antimicrobial thionin genes. Biosci. Biotechnol. Biochem. 2006, 70, 2410–2419.
• Kanno, Y.; Otomo, K.; Kenmoku, H.; Mitsuhashi, W.; Yamane, H.; Oikawa, H.; Toshima, H.; Matsuoka, M.; Sassa, T.; Toyomasu, T. Characterization of a rice gene family encoding type-A diterpene cyclases. Biosci. Biotechnol. Biochem. 2006, 70, 1702–1710.
• Lin, F.; Yamano, G.; Hasegawa, M.; Anzai, H.; Kawasaki, S.; Kodama, O. Cloning and functional analysis of caffeic acid 3-_O-methyltransferase from rice (Oryza sativa). J. Pestic. Sci._ 2006, 31, 47–53.

2005

• Tamogami, S.; Suzuki, M.; Toshima, H.; Hasegawa, M.; Kodama, O.; Noma, M. Volatile emission by [N-(-)-jasmonoyl]-alanylleucine from rice leaves (Oryza sativa L.). J. Pestic. Sci. 2005, 30, 225–227.
• Park, S.-H.; Nakajima, M.; Hasegawa, M.; Yamaguchi, I. Similarities and differences between the characteristics of gibberellin-binding protein and gibberellin 2-oxidases in adzuki bean (Vigna angularis) seedlings. Biosci. Biotechnol. Biochem. 2005, 69, 1508–1514.
• Koeduka, T.; Matsui, K.; Hasegawa, M.; Akakabe, Y.; Kajiwara, T. Rice fatty acid α-dioxygenase is induced by pathogen attack and heavy metal stress: activation through jasmonate signaling. J. Plant Physiol. 2005, 162, 912–920.
• Kiribuchi, K.; Jikumaru, Y.; Kaku, H.; Minami, E.; Hasegawa, M.; Kodama, O.; Seto, H.; Okada, K.; Nojiri, H.; Yamane, H. Involvement of the basic helix-loop-helix transcription factor RERJ1 in wounding and drought stress responses in rice plants. Biosci. Biotechnol. Biochem. 2005, 69, 1042–1044.

2004

• Jikumaru, Y.; Asami, T.; Seto, H.; Yoshida, S.; Yokoyama, T.; Obara, N.; Hasegawa, M.; Kodama, O.; Nishiyama, M.; Okada, K.; Nojiri, H.; Yamane, H. Preparation and biological activity of molecular probes to identify and analyze jasmonic acid-binding proteins. Biosci. Biotechnol. Biochem. 2004, 68, 1461–1466.
• Otomo, K.; Kanno, Y.; Motegi, A.; Kenmoku, H.; Yamane, H.; Mitsuhashi, W.; Oikawa, H.; Toshima, H.; Itoh, H.; Matsuoka, M.; Sassa, T.; Toyomasu, T. Diterpene cyclases responsible for the biosynthesis of phytoalexins, momilactones A, B, and oryzalexins A-F in rice. Biosci. Biotechnol. Biochem. 2004, 68, 2001–2006.
• Sawada, K.; Hasegawa, M.; Tokuda, L.; Kameyama, J.; Kodama, O.; Kohchi, T.; Yoshida, K.; Shinmyo, A. Enhanced resistance to blast fungus and bacterial blight in transgenic rice constitutively expressing OsSBP, a rice homologue of mammalian selenium-binding proteins. Biosci. Biotechnol. Biochem. 2004, 68, 873–880.
• Otomo, K.; Kenmoku, H.; Oikawa, H.; König, W.A.; Toshima, H.; Mitsuhashi, W.; Yamane, H.; Sassa, T.; Toyomasu, T. Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis. Plant J. 2004, 39, 886–893.
• Suzuki, M.; Hasegawa, M.; Kodama, O.; Toshima, H. Dihydrocoronatine, promising candidate for a chemical probe to study coronatine-, jasmonoid- and octadecanoid-binding protein. Biosci. Biotechnol. Biochem. 2004, 68, 1617–1620.
• Nakamura, K.; Isaka, T.; Toshima, H.; Kodaka, M. Selective synthesis of dehydroamino acids from threonines. Tetrahedron Lett. 2004, 45, 7221–7224.
• Fueki, S.; Tokiwano, T.; Toshima, H.; Oikawa, H. Biosynthesis of indole diterpenes, emindole, and paxilline: involvement of a common intermediate. Org. Lett. 2004, 6, 2697–2700.
• Ikunaga, Y.; Miyakawa, S.; Hasegawa, M.; Kasahara, Y.; Kodama, O.; Ohta, H. Degradation profiles of branched nonylphenol isomers by Sphingobium amiense and Sphingomonas cloacae. _ Soil Sci. Plant Nutr._ 2004, 50, 871–875.
• Matsui, H.; Nakamura, G.; Ishiga, Y.; Toshima, H.; Inagaki, Y.; Toyoda, K.; Shiraishi, T.; Ichinose, Y. Structure and expression of 12-oxophytodienoate reductase (subgroup I) genes in pea, and characterization of the oxidoreductase activities of their recombinant products. Mol. Genet. Genomics 2004, 271, 1–10.
• Cho, E.-M.; Okada, A.; Kenmoku, H.; Otomo, K.; Toyomasu, T.; Mitsuhashi, W.; Sassa, T.; Yajima, A.; Yabuta, G.; Mori, K.; Oikawa, H.; Toshima, H.; Shibuya, N.; Nojiri, H.; Omori, T.; Nishiyama, M.; Yamane, H. Molecular cloning and characterization of a cDNA encoding ent-cassa-12,15-diene synthase, a putative diterpenoid phytoalexin biosynthetic enzyme, from suspension-cultured rice cells treated with a chitin elicitor. Plant J. 2004, 37, 1–8.

2003

• Lin, F.; Hasegawa, M.; Kodama, O. Purification and identification of antimicrobial sesquiterpene lactones from yacon (Smallanthus sonchifolius) leaves. Biosci. Biotechnol. Biochem. 2003, 67, 2154–2159.
• Schmelz, E.A.; Engelberth, J.; Alborn, H.T.; O’Donnell, P.; Sammons, M.; Toshima, H.; Tumlinson, J.H., III. Simultaneous analysis of phytohormones, phytotoxins, and volatile organic compounds in plants. Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 10552–10557.

2002

• Itoh, S.; Kuwahara, S.; Hasegawa, M.; Kodama, O. Synthesis of the (17_R)- and (17_S)-isomers of volicitin, an elicitor of plant volatiles contained in the oral secretion of the beet armyworm. Biosci. Biotechnol. Biochem. 2002, 66, 1591–1596.
• Obara, N.; Hasegawa, M.; Kodama, O. Induced volatiles in elicitor-treated and rice blast fungus-inoculated rice leaves. Biosci. Biotechnol. Biochem. 2002, 66, 2549–2559.
• Atawong, A.; Hasegawa, M.; Kodama, O. Biosynthesis of rice phytoalexin: enzymatic conversion of 3β-hydroxy-9β-pimara-7,15-dien-19,6β-olide to momilactone A. Biosci. Biotechnol. Biochem. 2002, 66, 566–570.
• Toshima, H.; Oikawa, H.; Yada, H.; Ono, H.; Toyomasu, T.; Sassa, T. Total synthesis of (±)-_syn-copalol. Biosci. Biotechnol. Biochem._ 2002, 66, 2504–2510.

2001

• de Vries, Y.P.; Takahara, Y.; Ikunaga, Y.; Ushiba, Y.; Hasegawa, M.; Kasahara, Y.; Shimomura, H.; Hayashi, S.; Hirai, Y.; Ohta, H. Organic nutrient-dependent degradation of branched nonylphenol by Sphingomonas sp. YT isolated from a river sediment sample. Microbes Environ. 2001, 16, 240–249.
• Oikawa, H.; Toshima, H.; Ohashi, S.; König, W.A.; Kenmoku, H.; Sassa, T. Diversity of diterpene hydrocarbons in fungus Phoma betae. Tetrahedron Lett. 2001, 42, 2329–2332.
• Oikawa, H.; Toyomasu, T.; Toshima, H.; Ohashi, S.; Kawaide, H.; Kamiya, Y.; Ohtsuka, M.; Shinoda, S.; Mitsuhashi, W.; Sassa, T. Cloning and functional expression of cDNA encoding aphidicolan-16β-ol synthase: a key enzyme responsible for formation of an unusual diterpene skeleton in biosynthesis of aphidicolin. J. Am. Chem. Soc. 2001, 123, 5154–5155.
• Oikawa, A.; Ishihara, A.; Hasegawa, M.; Kodama, O.; Iwamura, H. Induced accumulation of 2-hydroxy-4,7-dimethoxy-1,4-benzoxazin-3-one glucoside (HDIMBOA-Glc) in maize leaves. Phytochemistry 2001, 56, 669–675.
• Ono, E.; Wong, H.L.; Kawasaki, T.; Hasegawa, M.; Kodama, O.; Shimamoto, K. Essential role of the small GTPase Rac in disease resistance of rice. Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 759–764.